Research

Main Content

2021

  • Amaral LM, Sandrim VC, Kutcher ME, Spradley FT, Cavalli RC, Tanus-Santos JE, Palei AC. Circulating total cell-free DNA levels are increased in hypertensive disorders of pregnancy and associated with prohypertensice factors and adverse clinical outcomes. Int J Mol Sci. 2021 Jan 8;22(2):564. doi: 10.3390/ijms22020564. PMID: 33429954
  • Ashraf S, Ashraf N, Yilmaz G, Harmancey R. Crosstalk between beta-adrenergic and insulin signaling mediates mechanistic target of rapamycin hyperactivation in livr of high-fat diet-fed male mice. Physiol Rep. 2021 Jul;9(13):e14958. doi: 10.14814/phy2.14958. PMID: 34231324
  • Ashraf UM, Hall DL, Rawls AZ, Alexander BT. Epigenetic processes during preeclampsia and effects on fetal development and chronic health. Clin Sci (Lond). 2021 Oct 15;135(19):2307-2327.
  • Bakrania BA, Spradley FT, Drummond HA, LaMarca B, Ryan MJ, Granger JP. Preeclampsia: linking placental ischemia with maternal endothelial and vascular dysfunction. Compr Physiol. 2020 Dec 9;11(1):1315-1349. doi: 10.1002/cphy.c200008.
  • Banek CT, Bradshaw JL, Coats LE, Alexander BT, Goulopoulou S. Getting it right: preventing drift in baseline cardiovascular phenotype when using Sprague-Dawley Rats. Am J Physiol. Heart Circ Physiol. 2021;321(3):H475-H478.
  • Braud L, Pini M, Stec DF, Manin S, Derumeaux G, Stec DE, Foresti R, Motterlini R. Increased Sirt1 secreted from visceral white adipose tissue is associated with improved glucose tolerance in obese Nrf2-deficient mice. Redox Biol. 2021 Jan;38:101805. doi: 10.1016/j.redox.2020.101805. Epub 2020 Nov 24. PMID: 33285413
  • Chade AR, Engel J, Hall ME, Eirin-Massat, A, Bidwell GL. Intra-renal Modulation of NF-kB Activity Attenuates Cardiac Injury in a Swine Model of CKD: A Renal-Cardio Axis. Am J Physiol Renal Physiol. 2021 Oct 1;321(4):F411-F423. doi: 10.1152/ajprenal.00158.2021. Epub 2021 Aug 16.
  • Chakraborty S, Meyers BA, Iwano H, Hall ME, Vlachos PP. A wavelet approach to the estimation of left ventricular early filling wave propagation velocity from color m-mode echocardiograms. Ultrasound Med Biol. 2021 Feb 2:S0301-5629(21)00034-X. doi: 10.1016/j.ultrasmedbio.2021.01.009. Online ahead of print. PMID: 33546924
  • Chen X, Ashraf S, Ashraf N, Harmancey R. UCP3 insufficiency exacerbates left ventricular diastolic dysfunction during angiotensin II-induced hypertension. J Am Heart Assoc. 2021 Sep 21;10(18):e022556. doi: 10.1161/JAHA.121.022556. Epub 2021 Sep 17.
  • Clemmer JS, Pruett WA, Lirette ST. Corrigendum:  racial and sex differences in the response to first-line antihypertensive therapy. Front Cardiovasc Med. 2021 Jan 21;7:643289. doi:10.3889/fcvm.2020.643289. eCollection 2020. PMID: 33585588
  • Clemmer JS, Pruett WA, Hester RL. In silico trial of baroreflex activation therapy for the treatment of obesity-induced hypertension. PLoS One. 2021 Nov 18;16(11):e0259917.doi: 10.1371/journal.pone.0259917. eCollection 2021.
  • Coats LE, Bamrick-Fernandez DR, Ariatti AM, Bakrania BA, Rawls AZ, Ojeda NB, Alexander BT. Stimulation of soluble guanylate cyclase diminishes intrauterine growth restriction in a rat model of placental ischemia. Am J Physiol Regul Integr Comp Physiol. 2021 Feb 1:320(2): R149-R161. doi: 10.1152/ajpregu.00234.2020. Epub 2020 Nov 11. PMID: 33175587
  • Coats LE, Bakrania BA, Bamrick-Fernandez DR, Ariatti AM, Rawls AZ, Ojeda NB, Alexander BT. Soluble guanylate cyclase stimulation in late gestation does not mitigate asymmetric IUGR or cardiovascular risk induced by placental ischemia in the rat. Am J Physiol Heart Circ Physiol. 2021 Mar 19. doi: 10.1152/ajpheart.00033.2021. Online ahead of print. PMID: 33739156
  • Creeden JF, Gordon DM, Stec DE, Hinds TD Jr. Bilirubin as a metabolic hormone: the physiological relevance of low levels. Am J Physiol Endocrinol Metab. 2021 Feb 1;320(2):E191-E207. doi: 10.1152/ajpendo.00405.2020. Epub 2020 Dec 7. PMID: 33284088
  • Daseke MJ 2nd, Chalise U, Becirovic-Agic M, Salomon JD, Cook LM, Case AJ, Lindsey ML. Neutrophil signaling during myocardial infarction wound repair. Cell Signal. 2021 Jan;77:109816. doi: 10.1016/j.cellsig.2020.109816. Epub 2020 Oct 24. PMID: 33122000
  • da Silva AA, Hall JE, Dai X, Wang Z, Salgado MC, do Carmo JM. Chronic antidiabetic actions of leptin: evidence from parabiosis studies for a CNS-derived circulating antidiabetic factor. Diabetes. 2021 Oct;70(10):2264-2274. doi: 10.2337/db21-0126. Epub 2021 Aug 3. PMID: 34344788
  • da Silva AA, Pinkerton MA, Spradley FT, Palei AC, Hall JE, do Carmo JM. Chronic CNS-mediated cardiometabolic actions of leptin: potential role of sex differences. Am J Physiol Regul Integr Comp Physiol. 2021 Feb 1;320(2):R173-R181. doi: 10.1152/ajpregu.00027.2020.Epub 2020 Nov 18. PMID: 33206555
  • da Silva AA, Hall JE, Dai X, Wang Z, Salgado MC, do Carmo JM. Evidence from parabiosis studies for a CNS-derived circulating antidiabetic circulating factor. Diabetes. 2021 Oct;70(10):2264-2274.doi: 10.2337/db21-0126. Epub 2021 Aug 3.
  • Deer E, Vaka VR, McMaster KM, Wallace K, Cornelius DC, Amaral LM, Cunningham MW, LaMarca B. Vascular endothelial mitochondrial oxidative stress in response to preeclampsia: a role for angiotension II type 1 autoantibodies. Am J Obstet Gynecol MFM. 2021 Jan; 3(1):100275. doi:10.1016/j.ajogmf.2020.100275. Epub 2020 Oct 27. PMID: 33451592
  • deMartelly VA, Dreixler J, Tung A, Mueller A, Heimburger S, Fazal AA, Naseem H, Lang R, Kruse E, Yamat M, Granger JP, Bakrania BA, Rodriguez-Kovacs J, Rana S, Shahul S. Long-term postpartum cardiac function and its association with preeclampsia. J Am Heart Assoc. 2021 Feb 23:e018526. doi: 10.1161/JAHA.120.018526. Online ahead of print. PMID: 33619970
  • do Carmo JM, et al., Sex differences in the impact of parental obesity on offspring cardiac SIRT3 expression, mitochondrial efficiency, and diastolic function early in life. Am J Physiol Heart Circ Physiol. 2021 Sep 1;321(3):H485-H495. doi: 10.1152/ajpheart.00176.2021. Epub 2021 Jul 23. PMID: 34296964
  • do Carmo JM, da Silva AA, Hall JE. Impact of Mineralocorticoid Receptor and Angiotensin II Type 1 Receptor Antagonism on Blood Pressure Regulation in Obese Zucker Rats: Role of Sex Differences. Am J Hypertens. 2021 Sep 22;34(9):999-1005. doi: 10.1093/ajh/hpaa170. PMID: 33075125; PMCID: PMC8457425.
  • Drummond HA. What evolutionary evidence implies about the identity of the mechanoelectrical couplers in vascular smooth muscle cells. Physiology (Bethesda). 2021 Sep 1;36(5):292-306. doi: 10.1152/physiol.00008.2021.
  • Duncan JW, Nemeth Z, Hildebrandt E, Granger JP, Ryan MJ, Drummond HA. Interleukin-17 induces hypertension but does not impair cerebrovascular function in pregnant rat. Pregnancy Hypertens. 2021 Jun;24:50-57. doi: 10.1016/j.preghy.2021.02.009. Epub 2021 Feb 23. PMID: 33677419
  • Fraher D, Mann RJ, Dubuisson MJ, Ellis MK, Yu T, Walder K, Ward AC, Winkler C, Gibert Y. The endocannabinoid system and retinoic acid signaling combine to influence bone growth. Mol Cell Endocrinol. 2021 Apr 9;529:111267. doi: 10.1016/j.mce.2021.111267. Online ahead of print. PMID: 33839219
  • Gava FN, da Silva AA, Dai X. Harmancey R, Ashraf S. Omoto ACM, Salgado MC, Moak SP, Li X, Hall JE, do Carmo JM. Restoration of cardiac function after myocardial infarction by long-term activation of the CNS leptin-melanocortin system. JACC Basic Transl Sci. 2021 Jan 25;6(1):55-70 doi: 10.1016/j.jacbts.2020.11.007.eCollection 2021 Jan. PMID: 33532666
  • Hall JE, et al. Obesity, kidney dysfunction, and inflammation: interactions in hypertension. Cardiovasc Res. 2021 Jul 7; 117(8):1859-1876. doi: 10.1093/cvr/cvaa336. PMID: 33258945
  • Hall ME., et al. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed program. Nature. 2021 Feb;590(7845):290-299. doi: 10.1038/s41586-021-03205-y. Epub 2021 Feb 10. PMID: 33568819
  • Hall ME., et al. Cigarette smoking, incident coronary heart disease, and coronary artery calcification in black adults: the Jackson heart study. J Am Heart Assoc. 2021 Apr 6;10(7):e017320. doi: 10.1161/JAHA.120.017320. Epub 2021 Mar 23. PMID: 33754833
  • Hall ME., et al. Development and validation of machine learning-based race-specific models to predict 10-year risk of heart failure: a multi-cohort analysis. Circulation. 2021 Apr 13. doi: 10.1161/CIRCULATIONAHA. 120.053134. Online ahead of print. PMID: 33845593
  • Hall ME., et al. Diagnosis, education, and care of patients with APOL1-associated nephropathy: A delphi consensus and systematic review. J Am Soc Nephrol. 2021 Apr 14:ASN.2020101399. doi: 10.1681/ASN.2020101399. Online ahead of print. PMID: 33853887
  • Hall ME., et al. Multi-omic profiling in black and white populations reveals novel candidate pathways in left ventricular hypertrophy and incident heart failure specific to black adults. Circ Genom Precis Med. 2021 May 21. doi: 10.1161/CIRCFEN.120.003191. Online ahead of print. PMID: 34019435
  • Hall ME, Cohen JB, Ard JD, Egan BM, Hall JE, Lavie CJ, Ma J, Ndumele CE, Schauer PR, Shimbo D; American Heart Association Council on Hypertension; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Lifestyle and Cardiometabolic Health; and Stroke Council. Weight-loss strategies for prevention and treatment of hypertension: a scientific statement from the american heart association. Hypertension. 2021 Nov;78(5):e38-e50. doi: 10.1161/HYP.0000000000000202. Epub 2021 Sep 20. PMID: 34538096.
  • Hall JE, Navar LG, Cowley AW Jr, Summers RL, Hester RL. Thomas George Coleman, PhD (1940-2021). Hypertension. 2021 Jun;77(6):1800-1803. doi: 10.1161/HYPERTENSIONAHA.121.17287. Epub 2021 May 3.PMID: 33934621 
  • Han Y, Taylor EB, Luthe D. Maize endochitinase expression in response to fall armyworm herbivory. J Chem Ecol. 2021 Jul;47(7):689-706. doi: 10.1007/s10886-021-01284-9. Epub 2021 May 31. PMID: 34056671
  • Hinds TD Jr., Kipp ZA, Xu Z, Yiannikouris FB, Morris AJ, Stec DF, Wahli W, Stec DE. Adipose-specific PPARα knockout mice have increased lipogenesis by PASK-SREBP1 signaling and a polarity shift to inflammatory macrophages in white adipose tissue (WAT). Cells, 11(1):4, 2021. PMCID:PMC8750478.
  • Huffman AM, Rezq S, Basnet J, Yanes Cardozo LL, Romero DG. SARS-CoV-2 Viral entry proteins in hyperandrogenemic female mice: implications for women with PCOS and COVID-19. Int J Mol Sci. 2021 Apr 25;22(9):4472. doi: 10.3390/ijms22094472. PMID: 33922918
  • Kalogeropoulos AP, Hall ME. Insights from MESA (multi-ethnic study of atherosclerosis): into the crypts of fat. J Am Coll Cardiol. 2021 Jun1;77(21):2653-2655. doi: 10.1016/j.jacc.2021.04.007. PMID: 34045021
  • Kamimura D, Cain-Shields LR, Clark D, Oshunbade AA, Ashley KE, Guild CS, Loprinzi PD, Newton R, Blaha MJ, Suzuki T, Butler J, Hall JE, Correa A, Hall ME. Physical activity, inflammation, corornary artery calcification, and incident coronary heart disease in african americans: insights from the jackson heart study. Mayo Clin Proc. 2021 Mar 10:S0025-6196(20)31375-6. doi: 10.1016/j.mayocp.2020.09.042. Online ahead of print. PMID: 33714604
  • Li X, Lu Q Qui Y, do Carmo JM, Wang Z, da Silva AA, Mouton A, Omoto ACM, Hall ME, Li J, Hall JE. Direct cardiac actions of the sodium glucose co-transporter 2 inhibitor empagliflozin improve myocardial oxidative phosphorylation and attenuate pressure-overload heart failure. J Am Heart Assoc. 2021 Mar 16;10(6):e018298. doi: 10.1161/JAHA.120.018298. Epub 2021 Mar 13. PMID: 33719499
  • Liu Y, Zhang H, Wu CY, Yu T, Fang X, Ryu JJ, Zheng B, Chen Z, Roman RJ, Fan F. 20-HETE-promoted cerebral blood flow autoregulation is associated with enhanced pericyte contractility. Prostaglandins Other Lipid Mediat. 2021 Mar 19;154:106548. doi: 10.1016/j.prostaglandins.2021.106548. Online ahead of print. PMID: 33753221
  • Ma M, Xu Y, Su Y, Ong SB, Hu X, Chai M, Zhao M, Li H, Fan X, Chen Y, Xu D, Xu X. Single-cell transcriptome analysis decipher new potential regulation mechanism of ACE2 and NPs signaling among heart failure patients infected with SARS-CoV-2. Front Cardiovasc Med. 2021 Feb 23;8:628885. doi: 10.3389/fcvm.2021.628885. eCollection 2021. PMID: 33718452
  • McClung DM, Kalusche WJ, Jones KE, Ryan MJ, Taylor EB. Hypertension and endothelial dusfunction in the pristane model of systemic lupus erythematosus. Physiol Rep. 2021 Feb;9(3):e14734. doi: 10.14814/phy2.14734. PMID: 33527772
  • Moore KH, Clemmer JS. Questioning the renoprotective role of L-type calcium channel blockers in chronic kidney disease using physiological modeling. Am J Physiol Renal Physiol https://pubmed.ncbi.nlm.nih.gov/34486399/. 321(4):F548-F557, 2021. 
  • Moore KH, Murphy HA, George EM. The glycocalyx: a central regulator of vascular function. Am J Physiol Regul Integr Comp Physiol. 2021 Jan 27. doi: 10.1152/ajpregu.00340.2020. Online ahead of print. PMID: 33501896
  • Moore KH, Murphy HA, Chapman H, George EM. Syncytialization alters the extracellular matrix and barrier function of placental trophoblasts. Am J Physiol Cell Physiol. 2021 Oct 1;321(4):C694-C703.
  • Mouton AJ, Flynn ER, Moak SP, Li X, da Silva AA, Wang Z, do Carmo JM, Hall ME, Hall JE. Interaction of obesity and hypertension on cardiac metabolic remodeling and survival following myocardial infarction. J Am Heart Assoc. 2021 Mar 5:e018212. doi: 10.1161/JAHA.120.018212. PMID: 33666098
  • Mouton AJ, Flynn ER, Moak SP, Aitken NM, Omoto ACM, Li X, da Silva AA, Wang Z, do Carmo JM, Hall JE. Dimethyl fumarate preserves left ventricular infarct integrity following myocardial infaction via modulation of cardiac macrophage and fibroblast oxidative metabolism. J Mol Cell Cardiol. 2021 May 21;158:38-48. doi: 10.1016/j.yjmcc.2021.05.008. Online ahead of print. PMID: 34023353
  • Nemeth Z, Ryan MJ, Granger JP, Drummond HA. Expression of exogenous epithelial sodium channel beta subunit in the mouse middle cerebral artery increases pressure-induced constriction. Am J Hypertens. 2021 Jun 23:hpab098. doi: 10.1093/ajh/hpab098. PMID: 34161569
  • Omoto ACM, Lataro RM, Silva TM, Silva LEV, Salgado HCS, Fazan-Jr. R. Heart rate fragmentation, a novel approach in heart rate variability analysis, is altered in rats 4 and 12 weeks after myocardial infarction. Med Biol Eng Comput, v.59 (11-12):2373-2382, 2021.
  • Palei AC, Martin HL, Wilson BA, Anderson CD, Granger JP, Spradley FT. Impact of hyperleptinemia during placental ischemia-induced hypertension in pregnant rats. Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00724.2019. Online ahead of print. PMID: 33710923
  • Palei AC, Granger JP, Spradley FT. Placental Ischemia Says "NO" to Proper NOS-Mediated Control of Vascular Tone and Blood Pressure in Preeclampsia. Int J Mol Sci. 2021 Oct 19;22(20):11261.doi: 10.3390/ijms222011261.
  • Parente JM, de Mello MMB, da Silva PHL, Omoto ACM, Pernomian L, de Oliveira IS, Mahmud Z, Fazan Jr R, Arantes EC, Schulz R, Castro MM. MMP inhibition attenuates hypertensive eccentric cardiac hypertrophy and dysfunction by preserving troponin I and dystrophin. Biochem Pharmacol. 2021 Nov;193:114744. doi: 10.1016/j.bcp.2021.114744. Epub 2021 Aug 25.
  • Rivera-Gonzalez O, Wilson NA, Coats LE, Taylor EB, Speed JS. Endothelin receptor antagonism improces glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice. Clin Sci (Lond). 2021 Jul 30;135(14):1773-1789. doi: 10.1042/CS20210549. PMID: 34278410
  • Shekhar S, Liu Y, Wang S, Zhang H, Fang X, Zhang J, Fan L, Zheng B, Roman RJ, Wang Z, Fan, F, Booz GW. Novel mechanistic insights and potential therapeutic impact of TRPC6 in neurovascular coupling and ischemic stroke. Int J Mol Sci. 2021 Feb 19;22(4):2074. doi: 10.3390/ijms22042074 PMID: 33669830
  • South AM, Alexander BT, Morrison JL, Sehgal A. Reply. J Pediatr. 2021 Mar;230:275-276. doi: 10.1016/j.jpeds.2020.11.051. Epub 2020 Nov 27. PMID: 33253734
  • Speed JS, Pruett WA, Lirette ST, Cook JJ, Phillips CL, Grayson BE. Cardiovascular risk factors following vertical sleeve gastrectomy in black americans compared with white americans. Obes Surg. 2021 Mar;31(3):1004-1012. doi: 10.1007/s11695-020-04938-x. Epub 2020 Aug 22. PMID: 32827094
  • Stec DE, Weigel B, Hinds TD Jr. Editorial: Oxidative stress, antioxidants, transcription factors, and assimilation of signal transduction pathways in obesity-related disorders. Frontiers in Pharmacology. 12:759468. doi: 10.3389/fphar.2021.759468, 2021. PMCID:PMC8452909.
  • Tahir UA, Katz DH, Zhao T, Ngo D, Cruz DE, Robbins JM, Chen ZZ, Peterson B, Benson MD, Shi X, Dailey L, Andersson C, Vasan RS, Gao Y, Shen C, Correa A, Hall, ME, Wang TJ, Clish CB, Wilson JG, Gerszten RE. Metabolic profiles and heart failure risk in black adults: insights from the Jackson Heart study. Circ Heart Fail. 2021 Jan;14(1):e007275. doi: 10.1161/CIRCHEARTFAILURE.120.007275. Epub 2021 Jan 19. PMID: 33464957
  • Taylor EB, George EM, Ryan MJ, Garrett MR, Sasser JM. Immunological comparison of pregnant dahl salt-sensitive and sprague dawley rats commonly used to model characteristics of preeclampsia. Am J Physiol Regul Integr Comp Physiol. 2021 Aug 1;321(2): R125-R138.
  • Taylor, EB. The complex role of adipokines in obesity, inflammation, and autoimmunity. Clin Sci (Lond). 2021 Mar 26;135(6):731-752. doi: 10.1042/CS20200895. PMID: 33729498
  • Waller JP, Burke SP, Engel J, Chade AR, Bidwell GL 3rd. A dose-escalating toxicology study of the candidate biologic ELP-VEGF. Sci Rep. 2021 Mar 18;11(1):6216. doi: 10.1038/s41598-021-85693-6. PMID: 33737643
  • Waller JP, Hallow JA, Peterson H, George EM, Bidwell GL 3rd. Elastin-like polypeptide: VEGF-B fusion protein for treatment of preeclampsia. Hypertension. 2021 Dec;78(6):1888-1901. doi: 10.11161/HYPERTENSIONAHA.121.17713. Epub 2021 Nov 1. PMID: 34719237
  • Wang Y, Angom RS, Kulkarni TA, Hoeppner LH, Pal K, Wang E, Tam A, Valiunas RA, Dutta SK, Ji B, Jarzebska N, Chen Y, Rodionov RN, Mukhopadhyay D. Dissecting VEGF-induced acute versus chronic vascular hyperpermeability: Essential roles of dimethylarginine dimethylaminohydrolase-1. iScience. 2021 Sep 30;24(10):103189. PMCID: PMC8521174. 10.1016/j.isci.2021.103189.
  • Watts SW, Alexander BT, Baylis C. Brown NJ, Cassis LA, Denton KM, Joe B, Lerman LO, Oparil S, Reckelhoff JF, Sandberg K, Touyz RM. Connecting generations of scientists in the council on hypertension through Harriet Dustan. Hypertension. 2021 Feb;77(2):296-307. doi: 10.1161/HYPERTENSIONAHA.120.16623. Epub 2021 Jan 4. PMID: 33390045
  • Wei J, Zhang J, Jiang S, Xu L, Qu L, Pang B, Jiang K, Wang L, Intapad S, Buggs J, Cheng F, Mohapatra S, Juncos LA, Osborn JL, Granger JP, Liu R. Macula densa NOS1β modulates renal hemodynamics and blood pressure during pregnancy: role in gestational hypertension. J Am Soc Nephrol. 2021 Oct;32(10):2485-2500. doi: 10.1681/ASN.2020070969. Epub 2021 Jun 14. PMID: 34127535; PMCID: PMC8722793.
  • Yang W, Li Q, Duncan JW, Bakrania BA, Bradshaw JL, Granger JP, Rana S. Spradley FT. Luteolin-induced vasorelaxation in uterine arteries from normal pregnant rats. Pregnancy Hypertens. 2021 Mar;23:11-17. doi: 10.1016/j.preghy.2020.10.008. Epub 2020 Oct 23. PMID: 33161224

  • Younes ST, Showmaker K, Johnson AC, Garrett MR, Ryan MJ. Single cell RNA sequencing reveals ferritin as a key mediator of autoimmune pre-disposition in a mouse model of systemic lupus erythematosus. Sci Rep. 2021 Dec 20;11(1):24245. doi: 10.1038/s41598-021-03649-2.